SELECTIVE LABELING OF PEPTIDES USING (DIENYL) IRON TRICARBONYL CATIONS

被引：23

作者：

CARVER, JA

FATES, B

KANEMAGUIRE, LAP

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 11期

关键词：

D O I：

10.1039/c39930000928

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dienyl cations of the type [(eta5-R.C6H6)Fe(CO)3]+ 1 are shown to be versatile electrophilic reagents for the rapid and selective labelling of peptides and proteins, with the affinity for amino acid residues decreasing markedly in the order: cys (SH) > his (-N=) > glu (delta-CO2-) >> alpha-NH2, lys (epsilon-NH2), ser (gamma-OH), asn (-CONH).

引用

页码：928 / 929

页数：2

共 6 条

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