REPEATED TREATMENT WITH FLUOXETINE DECREASES THE NUMBER OF SPONTANEOUSLY ACTIVE-CELLS PER TRACK IN FRONTAL-CORTEX

被引：11

作者：

CECI, A

FODRITTO, F

BORSINI, F

机构：

[1] Department of Pharmacology, Boehringer Ingelheim Italia, S.p.A., 20139 Milan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 271卷 / 01期

关键词：

FLUOXETINE; REPEATED ADMINISTRATION; FRONTAL CORTEX; SPONTANEOUSLY ACTIVE NEURON; (RAT);

D O I：

10.1016/0014-2999(94)90285-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Repeated (10 mg/kg i.p. x 14 days, once daily), but not acute (10 and 40 mg/kg i.p., 30 min), treatment with fluoxetine decreased the number of active neurons in the frontal cortex 30 min (-55%) or 24 h (-62%) after the last drug injection. This result supports the view that repeated, but not acute, treatment with fluoxetine decreases the function of the frontal cortex.

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页码：231 / 234

页数：4

相关论文

共 12 条

[1] 5-HYDROXYTRYPTAMINE2 AND 5-HYDROXYTRYPTAMINE1A RECEPTORS MEDIATE OPPOSING RESPONSES ON MEMBRANE EXCITABILITY IN RAT-ASSOCIATION CORTEX [J].

ARANEDA, R ;

ANDRADE, R .

NEUROSCIENCE, 1991, 40 (02) :399-412

[2]

ARTIGAS F, 1994, NEUROPSYCHOPHARMACOL, V10, pS2

[3] FLUOXETINE - A REVIEW OF RECEPTOR AND FUNCTIONAL-EFFECTS AND THEIR CLINICAL IMPLICATIONS [J].

BEASLEY, CM ;

MASICA, DN ;

POTVIN, JH .

PSYCHOPHARMACOLOGY, 1992, 107 (01) :1-10

[4] CHRONIC TREATMENT WITH FLUVOXAMINE INCREASES EXTRACELLULAR SEROTONIN IN FRONTAL-CORTEX BUT NOT IN RAPHE NUCLEI [J].

BEL, N ;

ARTIGAS, F .

SYNAPSE, 1993, 15 (03) :243-245

[5] EFFECTS OF SHORT-TERM AND LONG-TERM ADMINISTRATION OF FLUOXETINE ON THE MONOAMINE CONTENT OF RAT-BRAIN [J].

CACCIA, S ;

FRACASSO, C ;

GARATTINI, S ;

GUISO, G ;

SARATI, S .

NEUROPHARMACOLOGY, 1992, 31 (04) :343-347

[6]

DREVETS WC, 1992, PSYCHOPHARMACOL BULL, V28, P261

[7] RESPONSES OF CORTICAL-NEURONS TO STIMULATION OF THE NUCLEUS RAPHE MEDIANUS - A PHARMACOLOGICAL ANALYSIS OF THE ROLE OF INDOLEAMINES [J].

JONES, RSG .

NEUROPHARMACOLOGY, 1982, 21 (06) :511-520

[8] INHIBITION OF SPONTANEOUS AND EVOKED UNIT-ACTIVITY IN THE RAT MEDIAL PREFRONTAL CORTEX BY MESENCEPHALIC RAPHE NUCLEI [J].

MANTZ, J ;

GODBOUT, R ;

TASSIN, JP ;

GLOWINSKI, J ;

THIERRY, AM .

BRAIN RESEARCH, 1990, 524 (01) :22-30

[9]

Paxinos G., 2007, RAT BRAIN STEROTAXIC

[10] D-LYSERGIC-ACID DIETHYLAMIDE DIFFERENTIALLY AFFECTS THE DUAL ACTIONS OF 5-HYDROXYTRYPTAMINE ON CORTICAL-NEURONS [J].

PIERCE, PA ;

PEROUTKA, SJ .

NEUROPHARMACOLOGY, 1990, 29 (08) :705-712