ABSORPTION OF IPSAPIRONE ALONG THE HUMAN GASTROINTESTINAL-TRACT

被引：19

作者：

FUHR, U

STAIB, AH

HARDER, S

BECKER, K

LIERMANN, D

SCHOLLNHAMMER, G

ROED, IS

机构：

[1] UNIV FRANKFURT KLINIKUM,CTR RADIOL,FRANKFURT,GERMANY

[2] TROPON PHARMACEUT,DEPT BIOCHEM & MED,COLOGNE,GERMANY

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 38卷 / 01期

关键词：

IPSAPIRONE; AZAPIRONES; ABSORPTION; HF-CAPSULE; DRUG DELIVERY DEVICE; RECTAL APPLICATION; HUMAN GASTROINTESTINAL TRACT; SUSTAINED RELEASE;

D O I：

10.1111/j.1365-2125.1994.tb04327.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isapirone.HCl (5 mg) was administered orally, rectally and locally, by a remote control drug delivery device (HF-capsule) into different segments of the gastrointestinal tract, to four young healthy male adults. The relative systemic bioavailability of the drug from the colon and rectum was 2-3-fold greater than that from the upper gastrointestinal tract. This supports a rationale for a prolonged-release formulation.

引用

页码：83 / 86

页数：4

共 9 条

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HARDER, S ;

FUHR, U ;

BEERMANN, D ;

STAIB, AH .

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[3]

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[7]

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[8]

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