SERUM IMMUNE-RESPONSES TO THE PROTEINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS

被引：136

作者：

NELSON, EA ^{[1
]}

CHRISTOPHERHENNINGS, J ^{[1
]}

BENFIELD, DA ^{[1
]}

机构：

[1] S DAKOTA STATE UNIV,DEPT VET SCI,BROOKINGS,SD 57007

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1177/104063879400600402

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The antibody responses of pigs to porcine reproductive and respiratory syndrome virus (isolate VR-2332) were evaluated by indirect immunofluorescence, virus neutralization, and immunoblotting. All pigs in each group were positive by indirect immunofluorescence 14-21 days postexposure (DPE), and antibodies to specific viral proteins (15, 19 or 26 kD) were initially demonstrated by immunoblotting at 7-21 days DPE. Neutralizing antibodies were detected in only 2 pigs that were inoculated intranasally and given additional parenteral injections with adjuvant. These antibodies appeared much later, 51-70 DPE, than did antibodies detected by indirect immunofluorescence. The titer of the neutralizing antibodies increased until 127 DPE, after which the titers decreased, and 1 animal became seronegative for neutralizing antibody by 262 DPE.

引用

页码：410 / 415

页数：6

共 19 条

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