SKEWED REARRANGEMENT OF THE VH4-21 GENE DURING PRE-B ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：15

作者：

MALOUM, K ^{[1
]}

MAGNAC, C ^{[1
]}

PRITSCH, O ^{[1
]}

BINET, JL ^{[1
]}

MERLEBERAL, H ^{[1
]}

DIGHIERO, G ^{[1
]}

机构：

[1] INST PASTEUR,UNITE IMMUNOHEMATOL & IMMUNOPATHOL,F-75015 PARIS,FRANCE

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 17卷 / 5-6期

关键词：

VH GENE FAMILY EXPRESSION; VH 4 GENE EXPRESSION; ALL ACUTE LYMPHOBLASTIC LEUKEMIA;

D O I：

10.3109/10428199509056854

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-six pre-B acute lymphoblastic leukemias (ALL) were studied for VH family expression. Among the 35 detected rearrangements, VHI family genes were expressed in 7, VH2 in 1, VH3 in 18, VH4 in 6 and VH6 in 3. This expression is close to that expected according to the complexity of the system. The complete sequence of the 6 VH4 genes was examined in order to determine whether there is a skewed rearrangement of individual genes in this family. Our results indicate rearrangement of VH4-21 in 3 cases, 71-4 in one, 58P2 in one case and probably of a new germinal VH4 gene for the sixth case. All the genes were displaying an almost complete homology with their germinal VH counterparts. The 6 sequenced genes associated with 6 different D gene segments displaying a close homology with their germinal counterpart. JH4 segment was expressed in 3 cases and JH6 in the remaining 3. These results associated with previous results obtained by others indicate that there is skewed rearrangement of the VH4-21 gene in pre-B ALL. It is presently unknown whether this phenomenon is the consequence of a selective process or whether it reflects what normally occurs in the normal human functional repertoire, which could be more limited than the germline repertoire.

引用

页码：435 / 441

页数：7

共 23 条

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