POLYHYDROXYLATED 3-(N-PHENYL) CARBAMOYL-2-IMINOCHROMENE DERIVATIVES AS POTENT INHIBITORS OF TYROSINE KINASE P60(C-SRC)

被引：35

作者：

HUANG, CK

WU, FY

AI, YX

机构：

[1] Department of Pathology, University of Connecticut Health Center, Farmington

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

关键词：

D O I：

10.1016/0960-894X(95)00422-P

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several polyhydroxylated 3-(N-phenyl) carbamoly-2-iminochromene derivatives were synthesized and their inhibitory effects on tyrosine kinase p60(c-src) were evaluated. The structure-activity relationship reveals that the positions of the hydroxylation on both the iminochromene ring and the N-phenyl-ring of the carbamoyl group strongly affect the potency of the compounds.

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页码：2423 / 2428

页数：6

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