THE WIDELY USED ANESTHETIC AGENT PROPOFOL CAN REPLACE ALPHA-TOCOPHEROL AS AN ANTIOXIDANT

被引：125

作者：

AARTS, L ^{[1
]}

VANDERHEE, R ^{[1
]}

DEKKER, I ^{[1
]}

DEJONG, J ^{[1
]}

LANGEMEIJER, H ^{[1
]}

BAST, A ^{[1
]}

机构：

[1] VRIJE UNIV AMSTERDAM,LEIDEN AMSTERDAM CTR DRUG RES,DEPT PHARMACOCHEM,DIV MOLEC PHARMACOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

FEBS LETTERS | 1995年 / 357卷 / 01期

关键词：

LIPID PEROXIDATION; ALPHA-TOCOPHEROL; GLUTATHIONE; PROPOFOL; ANTIOXIDANT;

D O I：

10.1016/0014-5793(94)01337-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble alpha-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to alpha-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introducing propofol (2 and 5 mu M) restored the protective effect of GSH, Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes, These results suggest that propofol acts similarly to alpha-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

引用

页码：83 / 85

页数：3

共 17 条

[1] DIFFERENCES IN TOCOPHEROL-LIPID RATIOS IN ARDS AND NON-ARDS PATIENTS [J].