EXPRESSION OF THE HUMAN OX40 (HOX40) ANTIGEN IN NORMAL AND NEOPLASTIC TISSUES

被引：45

作者：

DURKOP, H

LATZA, U

HIMMELREICH, P

STEIN, H

机构：

[1] Institute of Pathology, Free University of Berlin, Klinikum Benjamin Franklin, Berlin

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 04期

关键词：

HUMAN OX40; TNFR SUPERFAMILY; LYMPHOMAS; IMMUNOHISTOLOGY;

D O I：

10.1111/j.1365-2141.1995.tb05413.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Ber-ACT35 mAb was raised against the human T-cell lymphotrophic virus (HTLV) 1-transformed, CD4(+) HUT 102 cell line and recognizes the human homologue of the OX40 (hOX40) antigen. The analysis of the expression of hOX40 by immunohistochemical techniques in malignant lymphomas, carcinomas and nonmalignant tissues of different organs shows that hOX40, expression was almost completely restricted to T lymphocytes. Besides T cells only a small subpopulation of macrophages in Langerhans' cell histiocytosis and a few blasts in B-cell non-Hodgkin's lymphoma (B-NHL) revealed a faint immunostaining with the Ber-ACT35 mAb. Furthermore, most of the hOX40(+) T-cells are CD4(+).

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页码：927 / 931

页数：5

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