PROTECTION FROM GENTAMICIN NEPHROTOXICITY BY CEPHALOTHIN AND CARBENICILLIN

被引：33

作者：

BLOCH, R ^{[1
]}

LUFT, FC ^{[1
]}

RANKIN, LI ^{[1
]}

SLOAN, RS ^{[1
]}

YUM, MN ^{[1
]}

MAXWELL, DR ^{[1
]}

机构：

[1] INDIANA UNIV,MED CTR,DEPT PATHOL,INDIANAPOLIS,IN 46223

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 15卷 / 01期

关键词：

D O I：

10.1128/AAC.15.1.46

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In rats, cephalothin exerts a protective effect upon the nephrotoxicity of gentamicin. To examine the possibility that this effect is also observed with carbenicillin, we gave the following (milligrams per kilogram) to rats daily for 14 days: gentamicin alone, 60; gentamicin plus cephalothin, 100, 500, or 1,000; gentamicin plus carbenicillin, 50, 100, 250, 500, or 1,000. A 500 mg/kg dose of cephalothin afforded significant partial protection from gentamicin nephrotoxicity, as did a 100-mg/kg dose of carbenicillin. Increasing doses of either drug failed to increase protection. The data suggest that in rats not only does carbenicillin afford some protection from gentamicin nephrotoxicity, but also that it does so at a lower dose than cephalothin. These findings may in part explain the divergent observations regarding the nephrotoxicity of cephalothin-gentamicin combination therapy in rats and humans.

引用

页码：46 / 49

页数：4

共 18 条

[1]

BARZA M, 1977, CURR CHEMOTHER, V2, P964

[2]

BRIER GL, 1975, 21 AM SOC CLIN PATH, P57

[3] EFFECT OF CEPHALOTHIN ON RENAL CORTICAL CONCENTRATIONS OF GENTAMICIN IN RATS [J].