AMINO-ACID SEQUENCE OF A VARIABLE REGION OF RABBIT-B4 LIGHT CHAIN FROM AN ANTI-SIII ANTIBODY - COMPARISON WITH LIGHT-CHAINS OF THE SAME SUBGROUP FROM ANTI-A-VARIANT CARBOHYDRATE ANTIBODIES

被引：1

作者：

CHERSI, A ^{[1
]}

APPELLA, E ^{[1
]}

CARTA, S ^{[1
]}

MAGE, R ^{[1
]}

机构：

[1] NCI,CELL BIOL LAB,BETHESDA,MD 20014

来源：

MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 08期

关键词：

D O I：

10.1016/0161-5890(79)90122-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of the variable region of a light chain from rabbit anti-type III polysaccharide antibody of b4 allotype was determined. Comparison with other sequenced rabbit kappa chains showed striking similarity to light chains with the rare amino terminal sequence Ile-Val-Met from antibodies elicited against Streptococcal A-variant carbohydrate and the carbohydrate of Micrococcus lysodeikticus. Residues 28-33 within the first complementarity determining region (CDR) were identical in sequence to the anti-A-variant carbohydrate antibody light chains but the third CDR differed considerably. An unusual insertion of three amino acids following homology position 58 was found which has not been previously observed in rabbit kappa chains. © 1979.

引用

页码：589 / 595

页数：7

共 20 条

[1] IMMUNOCHEMICAL STUDIES OF A ALLOTYPES OF RABBIT HEAVY-CHAIN VARIABLE REGIONS .2. IMMUNOLOGICAL PROPERTIES OF PEPTIDES FROM VARIABLE REGIONS OF HEAVY-CHAINS OF LIMITED HETEROGENEITY AND A3 ALLOTYPE [J].