NUCLEOLAR ORGANIZER REGIONS IN MENINGIOMA

被引：76

作者：

ORITA, T ^{[1
]}

KAJIWARA, K ^{[1
]}

NISHIZAKI, T ^{[1
]}

IKEDA, N ^{[1
]}

KAMIRYO, T ^{[1
]}

AOKI, H ^{[1
]}

机构：

[1] YAMAGUCHI UNIV,SCH MED,DEPT NEUROSURG,UBE,YAMAGUCHI 755,JAPAN

来源：

NEUROSURGERY | 1990年 / 26卷 / 01期

关键词：

Bromodeoxyuridine; Cell proliferation; Meningioma; Nucleolar organizer regions;

D O I：

10.1227/00006123-199001000-00006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seventy-eight cases of meningioma and related tumors were examined independently using a simple and reproducible argyrophilic method for the demonstration of nucleolar organizer regions (AgNORs) and staining with bromodeoxyuridine monoclonal antibody. The mean number of AgNORs per cell and the bromodeoxyuridine labeling index were shown to be linearly related (r = 0.84, P<0.001). The mean AgNOR number was 2.99 for meningeal sarcoma, 2.29 for anaplastic meningioma, 2.08 for hemangiopericytic meningioma, 1.72 for recurrent meningioma without atypical histological findings, and 1.52 for nonrecurrent meningioma. We noted that the mean number of AgNORs reflected the cellular kinetics of a tumor and was related to histological grade and clinical behavior.

引用

页码：43 / 46

页数：4