INDUCTION OF APOLIPOPROTEIN-E GENE-EXPRESSION IN HUMAN AND EXPERIMENTAL ATHEROSCLEROTIC LESIONS

被引：24

作者：

CRESPO, P

GONZALEZ, C

ORDOVAS, JM

ORTIZ, JM

RODRIGUEZ, JC

LEON, J

机构：

[1] UNIV CANTABRIA, FAC MED, DEPT BIOL MOLEC, E-39011 SANTANDER, SPAIN

[2] TUFTS UNIV, USDA, HUMAN NUTR RES CTR, BOSTON, MA 02111 USA

[3] UNIV CANTABRIA, FAC MED, DEPT BIOL CELULAR, E-39011 SANTANDER, SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92383-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypercholesterolemia and atherosclerosis were induced in New Zealand White rabbits by cholesterol feeding. Apolipoprotein E mRNA levels in livers were found to be slightly increased, as determined by Northern blots. Apolipoprotein E gene expression was dramatically induced in rabbit atherosclerotic aortas with respect to healthy aortas. However, apolipoprotein E mRNA levels in atherosclerotic aortas were low as compared with the hepatic mRNA levels of the same animals. Interestingly, we also found a significant increase in apolipoprotein E expression in human atheromata with respect to healthy aorta from the same individual. This is the first report on apo E gene induction in human atherosclerotic lesions. © 1990.

引用

页码：733 / 740

页数：8

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