4 GENES FOR THE CALPAIN FAMILY LOCATE ON 4 DISTINCT HUMAN-CHROMOSOMES

被引：53

作者：

OHNO, S

MINOSHIMA, S

KUDOH, J

FUKUYAMA, R

SHIMIZU, Y

OHMIIMAJOH, S

SHIMIZU, N

SUZUKI, K

机构：

[1] KEIO UNIV, SCH MED, DEPT MOLEC BIOL, TOKYO 108, JAPAN

[2] UNIV ARIZONA, DEPT MOLEC & CELLULAR BIOL, TUCSON, AZ 85721 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 04期

关键词：

D O I：

10.1159/000132937

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium dependent proteases (calpains. CAPNs, E.C.3.4.22.17) constitute a family of proteins which share a homologous cysteine-protease domain (large subunits. LI. L2. and L3) and an E-F hand Ca2+-binding domain (L1. L2. L3. and small subunit. S). We have mapped the genes for four calpain proteins (LI, L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human × mouse hybrid cell panel. The genes for calpain LI (CAPN1. large subunit of calpain I). L2 (CAPN2, large subunit of calpain II), L3 (CAPN3. a protein related to the large subunits), and S (CAPN4. a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1.15. and 19. respectively. © 1990 S. Karger AG, Basel.

引用

页码：225 / 229

页数：5

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