KINETICS OF ANTIBODY-RESPONSE TO HEPATITIS-B VIRUS DETERMINANTS AND TO RECOMBINANT VACCINES IN ITALY

被引：6

作者：

ZANETTI, AR

TANZI, E

ROMANO, L

VIGANO, P

CARGNEL, A

HOJVAT, S

ZUCKERMAN, AJ

机构：

[1] ROYAL FREE HOSP,SCH MED,WHO COLLABORATING CTR REFERENCE & RES VIRAL DIS,OFF DEAN,LONDON NW3 2PF,ENGLAND

[2] UNIV MILAN,INST VIROL,I-20122 MILAN,ITALY

[3] HOSP L SACCO,DIV INFECT DIS 2,MILAN,ITALY

[4] ABBOTT LABS,N CHICAGO,IL 60064

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 32卷 / 04期

关键词：

HEPATITIS-B GROUP DETERMINANT-A; SUBTYPE DETERMINANTS; RECOMBINANT VACCINES;

D O I：

10.1002/jmv.1890320405

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.

引用

页码：219 / 224

页数：6

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