ISOLATION AND REGIONAL LOCALIZATION OF 25 ANONYMOUS DNA PROBES ON A CHROMOSOME-13 HYBRID PANEL

被引：19

作者：

HOUWEN, RHJ

PAUTLER, SE

BARWELL, JA

ARDEN, K

BUCHANAN, JA

JAMES, CD

CAVENEE, WK

BUYS, CHCM

COWELL, JK

COX, DW

机构：

[1] HOSP SICK CHILDREN,RES INST,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA

[2] LUDWIG INST CANC RES,MONTREAL,QUEBEC,CANADA

[3] STATE UNIV GRONINGEN,DEPT HUMAN GENET,9700 AB GRONINGEN,NETHERLANDS

[4] IMPERIAL CANC RES FUND,DEPT HAEMATOL & ONCOL,LONDON WC2A 3PX,ENGLAND

[5] UNIV TORONTO,DEPT MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA

[6] UNIV TORONTO,DEPT PAEDIAT,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 2-3期

关键词：

D O I：

10.1159/000133120

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clones were isolated from two flow-sorted chromosome 13 libraries. Twenty-five clones were localized to various regions of chromosome 13, using a well-characterized panel of rodent x human hybrid cell lines. Eight DNA markers were localized to 13q14.2 --> q22, where the gene for Wilson disease, a recessive disorder of copper metabolism, was previously assigned. The new markers will be useful for the diagnosis of presymptomatic sibs of Wilson disease patients. We isolated six DNA clones proximal to the retinoblastoma gene, a region in which a translocation associated with rhabdomyosarcoma has been observed. Probes for both of these regions will be useful for the cloning of the genes involved in these diseases.

引用

页码：87 / 90

页数：4

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