FURTHER EVALUATION OF A MODIFIED MICRONUCLEUS ASSAY WITH V79-CELLS FOR DETECTION OF ANEUGENIC EFFECTS

被引:20
作者
SEELBACH, A
FISSLER, B
MADLE, S
机构
[1] Max-von-Pettenkofer-Institute, Federal Health Office, D-14195 Berlin
来源
MUTATION RESEARCH | 1993年 / 303卷 / 04期
关键词
MICRONUCLEUS TEST WITH V79-CELLS; ANEUGENIC EFFECT;
D O I
10.1016/0165-7992(93)90018-Q
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In an earlier publication, we reported on the development of a modified micronucleus assay with V79 cells enabling preferential detection of aneugen-induced micronuclei (Seelbach et al., 1993). Here we present a further evaluation of the modified micronucleus assay based on the investigation of seven further suspected aneugens. Five compounds gave positive results: cadmium chloride, chloral hydrate, hydroquinone, thimerosal and vinblastine. Econazole and pyrimethamine were negative. Up to now, our experience has shown that data produced by the modified V79/micronucleus assay are quite reliable: the variation of spontaneous micronucleus frequencies was low (0.8-1.7%) and the reproducibility of the data was good.
引用
收藏
页码:163 / 169
页数:7
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