EX-VIVO LEUKOCYTE ADHESION AND PROTEIN ADSORPTION ON TIN

被引：38

作者：

DION, I

ROQUES, X

MORE, N

LABROUSSE, L

CAIX, J

LEFEBVRE, F

ROUAIS, F

GAUTREAU, J

BAQUEY, C

机构：

[1] LAB BIOPHYS,F-33076 BORDEAUX,FRANCE

[2] HOP CARDIOL HAUT LEVEQUE,SERV CHIRURG CARDIOVASC PR BAUDET,F-33604 PESSAC,FRANCE

来源：

BIOMATERIALS | 1993年 / 14卷 / 09期

关键词：

TITANIUM NITRIDE; HEMOCOMPATIBILITY; LEUKOCYTE ADHESION; PROTEIN ADSORPTION;

D O I：

10.1016/0142-9612(93)90070-I

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Titanium nitride (TiN) is regarded as a potential biomaterial for blood-contact applications. Its in vitro haemocompatibility has been evaluated already and gave promising results. The purpose of this study was to continue studying its 'biological' behaviour through an ex vivo evaluation. The material was a physical vapour deposition elaborated TiN coating and the phenomena observed were leucocyte adhesion and albumin and fibrinogen adsorption. These ex vivo results were compared with in vitro results obtained previously. Two reference medical grade silicone elastomer and three TIN arterio-arterial extra-corporeal circuits were tested. No leucocyte was retained by TiN, as in in vitro experiments; the ex vivo fibrinogen adsorbed quantity was higher and albumin adsorption was about the same in in vitro ard in ex vivo situations. TIN can be considered as a suitable blood-contacting material.

引用

页码：712 / 719

页数：8

共 24 条

[1] BIOCOMPATIBILITY OF CARBON CARBON MATERIALS - BLOOD TOLERABILITY [J].

BAQUEY, C ;

BORDENAVE, L ;

MORE, N ;

CAIX, J ;

BASSECATHALINAT, B .

BIOMATERIALS, 1989, 10 (07) :435-440

[2]

BAQUEY C, 1991, MODERN ASPECTS OF PROTEIN ADSORPTION ON BIOMATERIALS, P3

[3] DIRECT INVIVO STUDY OF FLOWING BLOOD ARTIFICIAL SURFACE INTERACTIONS - AN ORIGINAL APPLICATION OF DYNAMIC ISOTOPIC TECHNIQUES [J].

BASSECATHALINAT, B ;

BAQUEY, C ;

LLABADOR, Y ;

FLEURY, A .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1980, 31 (12) :747-751

[4]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[5] THE SLIDING WEAR OF TITANIUM NITRIDE COATINGS [J].

BULL, SJ ;

RICKERBY, DS ;

JAIN, A .

SURFACE & COATINGS TECHNOLOGY, 1990, 41 (03) :269-283

[6]

CAIX J, 1993, IN PRESS J BIOMATER

[7] SURFACE MODIFICATION OF MEDICAL IMPLANTS AND SURGICAL DEVICES USING TIN LAYERS [J].

COLL, BF ;

JACQUOT, P .

SURFACE & COATINGS TECHNOLOGY, 1988, 36 (3-4) :867-878

[8]

DION I, 1992, BIOCERAMICS AND THE HUMAN BODY, P345

[9] BLOOD HEMOLYSIS BY CERAMICS [J].

DION, I ;

LAHAYE, M ;

SALMON, R ;

BAQUEY, C ;

MONTIES, JR ;

HAVLIK, P .

BIOMATERIALS, 1993, 14 (02) :107-110

[10]

DION I, 1992, INT J ARTIF ORGANS, V15, P457

← 1 2 3 →