CHEMICAL CHARACTERIZATION OF GLYCOSYLINOSITOLPHOSPHOLIPIDS OF HERPETOMONAS-SAMUELPESSOAI

被引：20

作者：

ROUTIER, FH

DASILVEIRA, EX

WAIT, R

JONES, C

PREVIATO, JO

MENDONCAPREVIATO, L

机构：

[1] UNIV FED RIO DE JANEIRO,CTR CIENCIAS SAUDE,INST MICROBIOL,BR-21994970 RIO JANEIRO,BRAZIL

[2] LAB CHIM BIOL,CNRS,UMR 111,F-59655 VILLENEUVE DASCQ,FRANCE

[3] CTR APPL MICROBIOL & RES,SALISBURY SP4 0JG,WILTS,ENGLAND

[4] NATL INST BIOL STAND & CONTROLS,POTTERS BAR EN6 3QG,HERTS,ENGLAND

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1995年 / 69卷 / 01期

关键词：

GLYCOINOSITOLPHOSPHOLIPID; HERPETOMONAS SAMUELPESSOAI; TRYPANOSOMATID; NMR-SPECTROSCOPY; FAB MASS SPECTROMETRY;

D O I：

10.1016/0166-6851(94)00202-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of two glycosylinositolphospholipids of the cell surface of the monoxenic protozoan Herpetomonas samuelpessoai have been deduced by methylation analysis, fast-atom bombardment mass spectrometry and two dimensional nuclear magnetic resonance spectroscopy. These glycolipids have features in common with the glycoinositolphospholipids of both Leishmania and Trypanosoma cruzi, resembling the former by the presence of the hybrid type core sequence Man alpha 1 --> 3(Man alpha 1 --> 6)Man alpha 1 --> 4GlcN alpha 1 --> 6 myo-inositol-1-PO4-lipid, while the 2-aminoethylphosphonate substituent on 0-6 of glucosamine and the presence of ceramide in place of glycerol lipids is more reminiscent of T. cruzi. Possible phylogenetic implications of these observations are discussed.

引用

页码：81 / 92

页数：12

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