EFFECTS OF SALVIA-LAVANDULIFOLIA VAHL SSP OXYODON EXTRACT ON PANCREATIC ENDOCRINE TISSUE IN STREPTOZOTOCIN-DIABETIC RATS

have investigated the antidiabetic activity of Salvia lavandulifolia ssp. oxyodon extract on rats pancreotomized by streptozotocin (STZ). At a dose of 10 mg dry residue/kg the extract produced: an increase in Langerhans islet number and size; an increase in pancreatic insulin content. When both Salvia extract (10 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabetic rats, a significant decrease in glycaemic level (>40%) and mortality index was achieved.