REVERSED-PHASE ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF DRUGS AND RELATED-COMPOUNDS USING UNDERIVATIZED SILICA AS THE STATIONARY PHASE

被引：61

作者：

CROMMEN, J

机构：

[1] Laboratoire d'Analyse des Médicaments, Université de Liège, Institut de Pharmacie

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 186卷 / DEC期

关键词：

D O I：

10.1016/S0021-9673(00)95290-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The retentionof organic compounds on silica in chomatographic systems with aqueous mobile phases has been investigated. The effects on retentionof the type of silica and the pH of the mobile phase in the acidic range have been studied. The samle behaviour is similar tothat observed in reversed-phase systems with an alkyl-bonded solid phase. The influence of the nature and the concentration of the mobile phase components on the retention of ionic samples has been examined. A retention model based on the distribution of ion pairs to the solid stationary phase is proposed. Different methods for the regulation of retention in these systems are given. Numerous examples of separations are presented. © 1979.

引用

页码：705 / 724

页数：20

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