SHORT-TERM PLASMA-RENIN ACTIVITY SUPPRESSION BY SALINE AND RELEASE OF A PLASMA ENDOGENOUS NA/K ATPASE INHIBITOR IN ESSENTIAL-HYPERTENSION

被引：9

作者：

BORGHI, C

BOSCHI, S

MUNARINI, A

MUSSI, A

COSTA, FV

AMBROSIONI, E

机构：

[1] The Department of Clinical Pharmacology and Therapeutics, University of Bologna, Bologna

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 02期

关键词：

Blood pressure; Na/K ATPase inhibitor; NaCl load; Plasma; Plasma renin activity suppression;

D O I：

10.1093/ajh/3.2.98

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

He present study was conducted in 15 essential hypertensives to evaluate the modifications of plasma levels of an endogenous Na/K ATPase inhibitor, blood pressure, forearm hemodynamics and plasma renin activity (PRA) elicited by an intravenous saline infusion (0.9% NaCl at the mean rate of 0.22 mL/min/kg body weight for 2 h). The response to saline was determined in the whole hypertensive population as well as in two subgroups of patients classified according to their rate of PRA suppression in response to volume expansion by comparison with normotensive controls (Normal-and Low-suppressors: N-S, L-S). Over the whole group of hypertensive patients, NaCl load provoked an increase in Na/K ATPase inhibitory activity, measured by enzyme-coupled assay, which was linearly related to PRA decline (r = 0.73) and to the increase in mean blood pressure (r = 0.57). These effects were clearly enhanced by considering L-S patients alone. Urinary Na/K ratio after saline infusion was significantly higher in L-S as result of a lesser potassium excretion in this subgroup. Our results support the hypothesis that acute volume expansion with saline causes an increase in plasma levels of an endogenous sodium pump inhibitor with hemodynamic effects and whose release is related to the individual handling of infused fluids and to the degree of renin-angiotensin-aldosterone suppression. Am J Hypertens 1990;3:98-104. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：98 / 104

页数：7

共 35 条

[1]

Cottier P.T., Weller J.M., Hoobler S.W., Sodium chloride excretion following salt loading in hypertensive subjects, Am J Med, 24, pp. 196-205, (1958)

[2]

Ullmann T.D., Blondheim S.H., Dikstein S., Ben-Ishay D., Water and salt excretion after intravenous salt loading in hypertensive subjects, Circulation, 19, pp. 729-734, (1959)

[3]

Lowenstein J., Beranbaum E.R., Chasis H., Baldwin D.S., Intrarenal pressure and exaggerated natriuresis in essential hypertension, Clin Sci, 38, pp. 359-374, (1970)

[4]

Luft F.C., Grim C.E., Fineberg N.S., Et al., Natriuretic response in labile hypertension, Am J Med Sci, 283, 3, pp. 119-128, (1982)

[5]

Costa F.V., Ambrosioni E., Montebugnoli L., Et al., Effects of a low-salt diet and of an acute salt loading on blood pressureand intralymphocytic sodium concentration in young subjects with borderline hypertension, Cli Sci, 61, pp. 21-23, (1981)

[6]

Sealey J.E., Kirshman J.D., Laragh J.H., Natriuretic activity in plasma and urine of salt-loaded man and sheep, J Clin Invest, 48, pp. 2210-2224, (1969)

[7]

Buckalew V.M., Nelson D.B., Natriuretic and sodium transport inhibitory activity in plasma of volume expanded dogs, Kidney Int, 5, pp. 12-22, (1974)

[8]

De Wardener H.E., Clarkson E.M., Concept of natriuretic hormone, Physiol Rev, 65, pp. 658-759, (1985)

[9]

Cloix J.F., Devynck M.A., Elghozi J.L., Et al., Plasma endogenous sodium pump inhibitor in essential hypertension, J Hypertens, 1, pp. 11-14, (1983)

[10]

Hamlyn J.M., Ringel R., Shaeffer J., Et al., A circulating inhibitor of (Na + K)ATPase associated with essential hypertension, Nature (London), 300, pp. 650-652, (1982)

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