DISTRIBUTION OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL AND 5-FLUOROURACIL BY ORAL-ADMINISTRATION IN MICE

The distribution of 1-hexylcarbamoyl-5-fluorouracil-6-14C (HCFU) and 5-fluorouracil-6-14C (5FU) was studied in mice following a single oral administration. When HCFU and 5FU were given orally to mice, they were readily absorbed from the gastrointestinal tract and the radioactivity was detected in various tissues and organs. Highest radioactivity after administration of HCFU was shown in the liver, kidneys, stomach wall and plasma, followed by the lungs, and adrenals. On the other hand, highest radioactivity after administration of 5FU was exhibited in the liver, myocardium, lungs, pancreas, spleen, kidneys, adrenals and gastro-intestinal wall. Distribution pattern and disappearance of HCFU were similar to those of 5FU. Marked difference in the distribution between HCFU and 5FU was detected only in the gastro-intestinal wall, namely, HCFU was retained for a long period in the stomach wall while 5FU did in the intestinal wall. © 1979, The Pharmaceutical Society of Japan. All rights reserved.