VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR-LIKE IMMUNOREACTIVITY IN HUMAN SWEAT GLANDS

被引：15

作者：

KUMMER, W

HERBST, WM

HEYM, C

机构：

[1] UNIV HEIDELBERG,INST ANAT & CELL BIOL,W-6900 HEIDELBERG,GERMANY

[2] UNIV ERLANGEN NURNBERG,DEPT DERMATOL,W-8520 ERLANGEN,GERMANY

来源：

NEUROSCIENCE LETTERS | 1990年 / 110卷 / 03期

关键词：

Immunohistochemistry; Man; Skin; Sweat gland; Sympathetic innervation; Vasoactive intestinal polypeptide; Vasoactive intestinal polypeptide receptor;

D O I：

10.1016/0304-3940(90)90853-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human sweat and sebaceous glands were studied immunohistochemically with a monoclonal antibody recognizing a vasoactive intestinal polypeptide (VIP) receptor. The staining pattern correlated well with the known distribution of sympathetic VIP-containing nerves in the human skin. The luminal cell layer of the sweat gland ducts and some acinar cells of the secretory coil of eccrine sweat glands were the major sites of VIP receptor-like immunoreactivity. From these findings and the known pharmacological actions of VIP it is concluded that a major role of VIP released from sympathetic nerves in the skin is to regulate chloride reabsorption from the primary sweat at the ductal segment. © 1990.

引用

页码：239 / 243

页数：5

共 23 条

[1] CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN NERVE-FIBERS IN THE HUMAN-SKIN - RELATION TO FIBERS CONTAINING SUBSTANCE-P-LIKE, SOMATOSTATIN-LIKE AND VASOACTIVE-INTESTINAL-POLYPEPTIDE-LIKE IMMUNOREACTIVITY [J].