ACTIVATION OF COAGULATION AND FIBRINOLYSIS DURING SURGERY, ANALYZED BY MOLECULAR MARKERS

Activation of hemostasis during surgery was investigated in 30 elective cases, who underwent either gastric (group G) or hepatic (group H) resection by a serial determination of various molecular markers such as fibrinopeptide A (FPA), fibrinopeptide Bβ15-42 (Bβ15-42) D-dimer, thrombin-antithrombin III complex (TAT) and plasmin-α2 plasmin inhibitor complex (PIC). In both groups, the values of FPA and TAT were significantly elevated intra-operatively, indicating an occurrence of hypercoagulable state. The degree of the elevation was more marked in group H, probably due to greater tissue damage during hepatic resection. Also in both groups, the values Bβ15-42 and PIC were significantly increased during surgery, while the amount of D-dimer was within normal range in most cases, indicating the occurrence of the primary fibrinolysis. These findings are compatible with our previous observations on the postoperative changes in hemostasis. There were statistically significant but variable correlations between the values of fibrinopeptides and the enzyme-inhibitor complexes. The absolute values of the molecular markers of fibrinolysis were always higher than those of coagulation, suggesting that a considerable amount of plasmin, rather than thrombin, is released by surgical tissue damages. © 1990.