PATERNAL INHERITANCE OF MITOCHONDRIAL-DNA IN MICE

被引：482

作者：

GYLLENSTEN, U

WHARTON, D

JOSEFSSON, A

WILSON, AC

机构：

[1] NEW YORK ZOOL SOC,BRONX,NY 10460

[2] FORDHAM UNIV,DEPT BIOL SCI,BRONX,NY 10458

[3] UNIV CALIF BERKELEY,DIV BIOCHEM & MOLEC BIOL,BERKELEY,CA 94720

来源：

NATURE | 1991年 / 352卷 / 6332期

关键词：

MATERNAL INHERITANCE; CHAIN-REACTION; POLYMERASE; DROSOPHILA; EVOLUTION; DELETIONS; SEQUENCE; STRAINS;

D O I：

10.1038/352255a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

FOR nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals 1. Using the polymerase chain reaction 2-3, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10(-4), relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.

引用

页码：255 / 257

页数：3

共 19 条

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