RELAXANT EFFECTS ON ILOPROST IN CANINE-CEREBRAL ARTERY

被引:4
作者
ZHANG, H
WEIR, B
DOI, M
KASUYA, H
COOK, D
机构
[1] UNIV ALBERTA, DEPT PHARMACOL, EDMONTON T6G 2H7, ALBERTA, CANADA
[2] UNIV ALBERTA, DEPT SURG, EDMONTON T6G 2H7, ALBERTA, CANADA
关键词
ILOPROST; EICOSANOID; OXYHEMOGLOBIN; RELAXATION; VASOSPASM;
D O I
10.1139/y92-092
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Iloprost caused relaxation of rings of canine cerebral arteries precontracted with prostaglandin F2-alpha or the thromboxane A2 analogue U46619, but it was without effect on arteries precontracted with potassium chloride. Pretreatment with iloprost did not significantly affect the concentration-response curve to any agent. Contractile responses to oxyhemoglobin were completed relaxed by iloprost. In arteries from animals with moderate cerebrovascular spasm, the response to prostaglandin F2-alpha. was also reduced by iloprost. The observation that iloprost relaxes the response to oxyhemoglobin to prostaglandin F2-alpha in spastic arteries may be of interest in the management of cerebral vasospasm.
引用
收藏
页码:712 / 716
页数:5
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