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IS THE MULTIDRUG TRANSPORTER A FLIPPASE

被引：675
作者：
HIGGINS, CF [1 ]
GOTTESMAN, MM [1 ]
机构：
[1] NCI,CELL BIOL LAB,BETHESDA,MD 20892
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 01期
关键词：
D O I：
10.1016/0968-0004(92)90419-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phenomenon of multidrug resistance is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. However, the mechanism of this pumping action remains unclear. In this article, we suggest that several properties of the multidrug transporter may be explained if it acts as a 'flippase' to transport drugs from the inner leaflet of the lipid bilayer to the outer or to the external medium.
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页码：18 / 21
页数：4
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