ALTERED MUSCLE METABOLISM SHOWN BY MAGNETIC-RESONANCE SPECTROSCOPY IN SICKLE-CELL DISEASE WITH LEG ULCERS

被引：9

作者：

NORRIS, SL

GOBER, JR

HAYWOOD, LJ

HALLS, J

BOSWELL, W

COLLETTI, P

TERK, M

机构：

[1] Los Angeles County + USC Medical Center, Los Angeles

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 01期

关键词：

MAGNETIC RESONANCE SPECTROSCOPY; MUSCLE METABOLISM; LEG ULCERS; SICKLE CELL ANEMIA; ISCHEMIA HYPOXIA;

D O I：

10.1016/0730-725X(93)90419-E

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We performed P-31 magnetic resonance spectroscopy.of gastrocnemius muscle at rest in 7 normal volunteers and 12 patients with sickle cell disease (7 with leg ulcers and 5 without leg ulcers but with painful crises). We measured intracellular pH and ratios of Pi to ATP, PCr to ATP and PCr to Pi (Pi = inorganic phosphate, ATP = adenosine triphosphate, and PCr = phosphocreatine). Magnetic resonance arteriograms were also performed. Significant differences were found for PCr/Pi ratios between normals and sickle cell disease patients with leg ulcers (p < 0.008). Magnetic resonance arteriograms were normal in volunteers and patients with sickle cell disease. The altered high energy phosphate metabolism in sickle cell disease with leg ulcers is consistent with muscle ischemia or hypoxia.

引用

页码：119 / 123

页数：5

共 15 条

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