EQUIVALENCE OF A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY AND A BIOASSAY OF AZITHROMYCIN IN HUMAN SERUM SAMPLES

被引：39

作者：

RIEDEL, KD

WILDFEUER, A

LAUFEN, H

ZIMMERMANN, T

机构：

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 576卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80212-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two sensitive methods for the determination of the azalide antibiotic azithromycin in human serum were compared. High-performance liquid chromatography (HPLC) and a microbiological assay were simultaneously applied to 768 serum samples obtained in a clinical study. There was excellent agreement between the azithromycin concentrations measured by HPLC and by the bioassay. The correlation coefficient for the two methods was r2 = 0.96. The precision and the sensitivity of the methods were found to be very similar.

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页码：358 / 362

页数：5

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