EFFECT OF LYMPHOBLASTOID ALFA-INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-C HAVING DIFFERENT GENOTYPIC SUBTYPE OF HEPATITIS-C VIRUS

被引:8
作者
CHAYAMA, K
TSUBOTA, A
ARASE, Y
SAITOH, S
IKEDA, K
MATSUMOTO, T
SAKAI, Y
KOBAYASHI, M
MORINAGA, T
KUMADA, H
机构
[1] Department of Gastroenterology and Liver Research Laboratory Toranomon Hospital, Tokyo
[2] Department of Molecular Biology, TEIJIN Ltd, Hino
来源
GASTROENTEROLOGIA JAPONICA | 1993年 / 28卷
关键词
D O I
10.1007/BF02989204
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Five subtypes of hepatitis C virus (Pt[I], K1[II], K2a[III], K2b[IV] and Tr[V]) have been suggested based on the nucleotide sequence of the non-structural five region. To assess the susceptibility of each subtype to interferon therapy, we developed a one-step method which allows quick determination of subtype using polymerase chain reaction with a mixed primer set deduced from the sequence of each subtype. We were able to determine the subtype of 69 of 80 (86.3%) Japanese patients who received natural alfa-interferon treatment. The incidence of each subtype was K1: 53 (76.8%), K2a: 14 (20.3%), K2b: 3 (4.3%) and Tr: 1 (1.4%). Interferon was administered to these patients and found to be effective in 28 of 51 (54.9%) patients with K1 subtype and in 16 of 18 (88.9%) patients with other subtypes (P< 0.01). These data show that K1 is a major subtype in Japan and relatively resistant to interferon treatment. © 1993 The Japanese Society of Gastroenterology.
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收藏
页码:45 / 47
页数:3
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