EFFECT OF LYMPHOBLASTOID ALFA-INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-C HAVING DIFFERENT GENOTYPIC SUBTYPE OF HEPATITIS-C VIRUS

被引：8

作者：

CHAYAMA, K

TSUBOTA, A

ARASE, Y

SAITOH, S

IKEDA, K

MATSUMOTO, T

SAKAI, Y

KOBAYASHI, M

MORINAGA, T

KUMADA, H

机构：

[1] Department of Gastroenterology and Liver Research Laboratory Toranomon Hospital, Tokyo

[2] Department of Molecular Biology, TEIJIN Ltd, Hino

来源：

GASTROENTEROLOGIA JAPONICA | 1993年 / 28卷

关键词：

D O I：

10.1007/BF02989204

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Five subtypes of hepatitis C virus (Pt[I], K1[II], K2a[III], K2b[IV] and Tr[V]) have been suggested based on the nucleotide sequence of the non-structural five region. To assess the susceptibility of each subtype to interferon therapy, we developed a one-step method which allows quick determination of subtype using polymerase chain reaction with a mixed primer set deduced from the sequence of each subtype. We were able to determine the subtype of 69 of 80 (86.3%) Japanese patients who received natural alfa-interferon treatment. The incidence of each subtype was K1: 53 (76.8%), K2a: 14 (20.3%), K2b: 3 (4.3%) and Tr: 1 (1.4%). Interferon was administered to these patients and found to be effective in 28 of 51 (54.9%) patients with K1 subtype and in 16 of 18 (88.9%) patients with other subtypes (P< 0.01). These data show that K1 is a major subtype in Japan and relatively resistant to interferon treatment. © 1993 The Japanese Society of Gastroenterology.

引用

页码：45 / 47

页数：3

共 10 条

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