NITRIC-OXIDE SYNTHESIS AND ACTION IN AN INVERTEBRATE BRAIN

被引：136

作者：

ELPHICK, MR ^{[1
]}

GREEN, IC ^{[1
]}

OSHEA, M ^{[1
]}

机构：

[1] UNIV SUSSEX, SCH BIOL SCI, BIOCHEM LAB, BRIGHTON BN1 9QJ, E SUSSEX, ENGLAND

来源：

BRAIN RESEARCH | 1993年 / 619卷 / 1-2期

关键词：

NITRIC OXIDE SYNTHASE; SOLUBLE GUANYLYL CYCLASE; CGMP; CALMODULIN; LOCUST; SCHISTOCERCA-GREGARIA;

D O I：

10.1016/0006-8993(93)91632-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) is synthesized in mammalian neurons by Ca2+/calmodulin activated NO synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase are present in the brain of the locust Schistocerca gregaria. Our observations indicate, for the first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.

引用

页码：344 / 346

页数：3

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