ANTIBODIES TO HEPATITIS-C VIRUS (HCV) AND TRANSAMINASE CONCENTRATION IN CHRONIC-HEMODIALYSIS PATIENTS - A STUDY WITH 2ND-GENERATION ASSAYS

被引:58
作者
FABRIZI, F [1 ]
RAFFAELE, L [1 ]
BACCHINI, G [1 ]
GUARNORI, I [1 ]
PONTORIERO, G [1 ]
ERBA, G [1 ]
LOCATELLI, F [1 ]
机构
[1] HOSP LECCO,DEPT NEPHROL,I-22053 LECCO,ITALY
关键词
HEPATITIS-C VIRUS; TRANSAMINASE LEVELS; HEMODIALYSIS;
D O I
10.1093/ndt/8.8.744
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
We used first- and second-generation assays such as Ortho 1, Ortho 2 and 4-RIBA to define prevalence and risk factors for anti-HCV antibodies in haemodialysed patients. Forty-nine (24%) subjects were found to be anti-HCV positive. Anti-HCV positivity was related to duration of dialysis and past or current elevations of GOT and GPT; the frequency of transfused patients was greater in HCV-positive than in HCV-negative subjects; there were 31 patients (prevalence of 20%) with anti-HCV antibodies among non-transfused patients. These findings show that, tested by second-generation assays, HCV infection is detected more than twice as commonly in haemodialysis patients and may be responsible for a significant proportion of liver disease in this clinical setting. Acquisition of hepatitis C virus by dialysis patients is not only through blood transfusions but also secondary to hepatitis C virus presence within the unit itself.
引用
收藏
页码:744 / 747
页数:4
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