PHARMACOLOGICAL EFFECTS OF BUTYLIDENEPHTHALIDE

被引：30

作者：

KO, WC

CHANG, LD

WANG, GY

LIN, LC

机构：

[1] TAIPEI MED COLL,DEPT PHARMACOL,TAIPEI 110,TAIWAN

[2] NATL TAIWAN UNIV,DEPT CHEM,TAIPEI 10764,TAIWAN

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 06期

关键词：

LIGUSTICUM WALLICHII FRANCH; BUTYLIDENEPHTHALIDE; ANTISPASMODIC; ANTIHYPERTENSIVE; CORONARY DILATOR;

D O I：

10.1002/ptr.2650080602

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo, Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin-induced T-wave lowering of the ECG in anaesthetized rats. It also dose-dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro, Bdph non-competitively antagonized adrenaline-induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA-induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20 degrees C, but not at 30 degrees C. Bdph might be a useful coronary dilator and antihypertensive drug.

引用

页码：321 / 326

页数：6

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