GENETIC-MAP OF THE REGION SURROUNDING THE RETROVIRUS RESTRICTION LOCUS, FV1, ON MOUSE CHROMOSOME-4

被引：13

作者：

STOYE, JP ^{[1
]}

KAUSHIK, N ^{[1
]}

JEREMIAH, S ^{[1
]}

BEST, S ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

来源：

MAMMALIAN GENOME | 1995年 / 6卷 / 01期

关键词：

D O I：

10.1007/BF00350890

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Friend virus susceptibility-1 (Fv1) gene maps to mouse Chromosome (Chr) 4 close to a cluster of four endogenous murine leukemia viruses (MLVs). To investigate the feasibility of cloning Fv1 by a positional approach, we have performed an extensive genetic analysis of this region of Chr 4. We have typed 368 backcross mice for the four proviruses, Nppa, Lck, and D4Smh6b. Recombinant animals were screened in a hierarchical fashion with a variety of other markers, including Fv1 and the isozyme marker Gpd1. A detailed genetic map of the region surrounding Fv1 was derived. Three markers, Xmv9, Nppa, and Iap3rc11, were identified that showed no recombination with Fv1. By combining backcross and recombinant inbred strain data, we estimated that Xmv9 and Nppa must lie within 0.6 cM of one another and Fv1.

引用

页码：31 / 36

页数：6

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