GENE-THERAPY FOR HIV-INFECTION

被引：18

作者：

LEVER, AML

机构：

[1] University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge

来源：

BRITISH MEDICAL BULLETIN | 1995年 / 51卷 / 01期

关键词：

D O I：

10.1093/oxfordjournals.bmb.a072944

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The genetic approach to HIV infection is still very young and a number of different stages in the viral life cycle are being studied as targets for gene therapy, using a wide variety of modalities for gene delivery, Several gene therapy protocols for AIDS have been approved and when this article is published these may be in progress, In this chapter the scientific background to these in vivo studies is reviewed.

引用

收藏

页码：149 / 166

页数：18

相关论文

共 77 条

[1] MUTATIONS OF RNA AND PROTEIN SEQUENCES INVOLVED IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PACKAGING RESULT IN PRODUCTION OF NONINFECTIOUS VIRUS [J].

ALDOVINI, A ;

YOUNG, RA .

JOURNAL OF VIROLOGY, 1990, 64 (05) :1920-1926

[2] INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) REPLICATION BY HIV-TRANS-ACTIVATED ALPHA-2-INTERFERON [J].

BEDNARIK, DP ;

MOSCA, JD ;

RAJ, NBK ;

PITHA, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :4958-4962

[3] INVITRO EFFECT OF ANTISENSE OLIGONUCLEOTIDES ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE TRANSCRIPTION [J].

BORDIER, B ;

HELENE, C ;

BARR, PJ ;

LITVAK, S ;

SARIHCOTTIN, L .

NUCLEIC ACIDS RESEARCH, 1992, 20 (22) :5999-6006

[4] SPECIFIC ABLATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TAT-EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES [J].

BRADY, HJM ;

MILES, CG ;

PENNINGTON, DJ ;

DZIERZAK, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :365-369

[5] CELLS INDUCED TO EXPRESS A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GENE MUTANT INHIBIT THE SPREAD OF WILD-TYPE VIRUS [J].

BUCHSCHACHER, GL ;

FREED, EO ;

PANGANIBAN, AT .

HUMAN GENE THERAPY, 1992, 3 (04) :391-397

[6] HUMAN-IMMUNODEFICIENCY-VIRUS VECTORS FOR INDUCIBLE EXPRESSION OF FOREIGN GENES [J].

BUCHSCHACHER, GL ;

PANGANIBAN, AT .

JOURNAL OF VIROLOGY, 1992, 66 (05) :2731-2739

[7] PREVENTION OF HIV-1 GLYCOPROTEIN TRANSPORT BY SOLUBLE CD4 RETAINED IN THE ENDOPLASMIC-RETICULUM [J].

BUONOCORE, L ;

ROSE, JK .

NATURE, 1990, 345 (6276) :625-628

[8] SELECTIVE KILLING OF CD4+ CELLS HARBORING A HUMAN IMMUNODEFICIENCY VIRUS-INDUCIBLE SUICIDE GENE PREVENTS VIRAL SPREAD IN AN INFECTED CELL-POPULATION [J].

CARUSO, M ;

KLATZMANN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :182-186

[9] DUAL-TARGET INHIBITION OF HIV-1 INVITRO BY MEANS OF AN ADENOASSOCIATED VIRUS ANTISENSE VECTOR [J].

CHATTERJEE, S ;

JOHNSON, PR ;

WONG, KK .

SCIENCE, 1992, 258 (5087) :1485-1488

[10] MULTITARGET-RIBOZYME DIRECTED TO CLEAVE AT UP TO 9 HIGHLY CONSERVED HIV-1 ENV RNA REGIONS INHIBITS HIV-1 REPLICATION POTENTIAL EFFECTIVENESS AGAINST MOST PRESENTLY SEQUENCED HIV-1 ISOLATES [J].

CHEN, CJ ;

BANERJEA, AC ;

HARMISON, GG ;

HAGLUND, K ;

SCHUBERT, M .

NUCLEIC ACIDS RESEARCH, 1992, 20 (17) :4581-4589

← 1 2 3 4 5 6 7 8 →