(8A-ALPHA,12A-ALPHA,13A-ALPHA)-5,8,8A,9,10,11,12,12A,13,13A-DECAHYDRO-3-METHOXY-12-(METHYLSULFONYL)-6H-ISOQUINO[2,1-G][1,6]NAPHTHYRIDINE, A POTENT AND HIGHLY SELECTIVE ALPHA2-ADRENOCEPTOR ANTAGONIST

被引：40

作者：

CLARK, RD ^{[1
]}

REPKE, DB ^{[1
]}

KILPATRICK, AT ^{[1
]}

BROWN, CM ^{[1
]}

MACKINNON, AC ^{[1
]}

CLAGUE, RU ^{[1
]}

SPEDDING, M ^{[1
]}

机构：

[1] SYNTEX RES CTR,DEPT PHARMACOL,EDINBURGH EH14 4AP,SCOTLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 09期

关键词：

D O I：

10.1021/jm00129a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2034 / 2036

页数：3

共 18 条

[1] Concerning the synthesis of 2.3-derivatives of pyridins. [J].

Baumgarten, P ;

Dornow, A .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1939, 72 :563-566

[2] ALPHA-2-ADRENOCEPTOR AGONISTS INDUCE MYDRIASIS IN THE RAT BY AN ACTION WITHIN THE CENTRAL NERVOUS-SYSTEM [J].

BERRIDGE, TL ;

GADIE, B ;

ROACH, AG ;

TULLOCH, IF .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 78 (03) :507-515

[3] ALPHA-ADRENORECEPTOR REAGENTS .1. SYNTHESIS OF SOME 1,4-BENZODIOXANS AS SELECTIVE PRE-SYNAPTIC ALPHA-2-ADRENORECEPTOR ANTAGONISTS AND POTENTIAL ANTI-DEPRESSANTS [J].

CHAPLEO, CB ;

MYERS, PL ;

BUTLER, RCM ;

DOXEY, JC ;

ROACH, AG ;

SMITH, CFC .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :823-831

[4]

Clark R D, 1986, Prog Med Chem, V23, P1, DOI 10.1016/S0079-6468(08)70339-4

[5] SYNTHESIS OF 3-SUBSTITUTED AND 3,4-DISUBSTITUTED 3,4-DIHYDRO-1(2H)-ISOQUINOLONES BY CONDENSATION OF LITHIATED N,N-DIETHYL-ORTHO-TOLUAMIDE WITH IMINES [J].

CLARK, RD ;

JAHANGIR .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (24) :5378-5382

[6] PHARMACOLOGICAL CHARACTERIZATION OF PRESYNAPTIC ALPHA-ADRENOCEPTORS REGULATING CHOLINERGIC ACTIVITY IN GUINEA-PIG ILEUM [J].

DREW, GM .

BRITISH JOURNAL OF PHARMACOLOGY, 1978, 64 (02) :293-300

[7]

GILLESPIE JS, 1980, ADRENERGIC ACTIVAT 1

[8] NOVEL VASOPRESSIN ANALOGS THAT HELP DEFINE A MINIMUM EFFECTIVE ANTAGONIST PHARMACOPHORE [J].

HUFFMAN, WF ;

ALI, FE ;

BRYAN, WM ;

CALLAHAN, JF ;

MOORE, ML ;

SILVESTRI, JS ;

YIM, NCF ;

KINTER, LB ;

MCDONALD, JE ;

ASHTONSHUE, D ;

STASSEN, FL ;

HECKMAN, GD ;

SCHMIDT, DB ;

SULAT, L .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1759-1760

[9] ALPHA2-ADRENOCEPTOR ANTAGONISM AND OTHER PHARMACOLOGICAL ANTAGONIST PROPERTIES OF SOME SUBSTITUTED BENZOQUINOLIZINES AND YOHIMBINE INVITRO [J].

LATTIMER, N ;

MCADAMS, RP ;

RHODES, KF ;

SHARMA, S ;

TURNER, SJ ;

WATERFALL, JF .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1984, 327 (04) :312-318

[10] PHARMACOLOGICAL PROFILE OF A NEW POTENT AND SPECIFIC ALPHA-2-ADRENOCEPTOR ANTAGONIST, L-657,743 [J].

PETTIBONE, DJ ;

CLINESCHMIDT, BV ;

LOTTI, VJ ;

BALDWIN, JJ ;

HUFF, JR ;

RANDALL, WC ;

VACCA, J ;

YOUNG, SD .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1987, 336 (02) :169-175

← 1 2 →