TESTOSTERONE INCREASES LIPOLYSIS AND THE NUMBER OF BETA-ADRENOCEPTORS IN MALE-RAT ADIPOCYTES

被引：177

作者：

XU, XF ^{[1
]}

DEPERGOLA, G ^{[1
]}

BJORNTORP, P ^{[1
]}

机构：

[1] GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT MED,S-41345 GOTHENBURG,SWEDEN

来源：

ENDOCRINOLOGY | 1991年 / 128卷 / 01期

关键词：

D O I：

10.1210/endo-128-1-379

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of androgen status on the regulation of lipolysis and number of beta-adrenoceptors in isolated adipocytes was studied in male rats. Castration resulted in decreased catecholamine-induced as well as forskolin-induced lipolysis. beta-adrenoceptor number, examined by a whole cell cyanopindolol binding assay, was also diminished to a similar extent. Testosterone treatment of castrated rats normalized lipolysis as well as beta-adrenoceptor number. These results demonstrate that testosterone stimulates catecholamine-induced lipolysis in vivo by increasing the number of beta-adrenoceptors as well as the activity of adenylate cyclase, confirming previous in vitro studies performed in adipose precursor cells.

引用

页码：379 / 382

页数：4

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