MODULATION OF C-KIT MESSENGER-RNA AND PROTEIN BY HEMATOPOIETIC GROWTH-FACTORS

被引：72

作者：

WELHAM, MJ

SCHRADER, JW

机构：

[1] Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 05期

关键词：

D O I：

10.1128/MCB.11.5.2901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effects of various hemopoietins on c-kit mRNA and protein expression. Interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and erythropoietin, but not IL-4, down-regulated levels of c-kit mRNA expressed by mast cells and stem cell progenitors. The effect of IL-3 was dominant and independent of cell growth or viability and was paralleled by reduced expression in c-kit protein. These observations indicate that regulation of c-kit expression is closely interlinked with the molecular mechanisms triggered by erythropoietin, IL-3, and granulocyte-macrophage colony-stimulating factor.

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页码：2901 / 2904

页数：4

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