PLATELET-DERIVED GROWTH-FACTOR IN DUPUYTRENS DISEASE

被引：40

作者：

BADALAMENTE, MA

HURST, LC

GRANDIA, SK

SAMPSON, SP

机构：

[1] Department of Orthopaedics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1992年 / 17A卷 / 02期

关键词：

D O I：

10.1016/0363-5023(92)90414-K

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

引用

页码：317 / 323

页数：7

共 26 条

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