CHANGES IN ALLOZYME PATTERN OF THE PROTOZOAN PARASITE GIARDIA-INTESTINALIS

被引:8
作者
ANDREWS, RH
MAYRHOFER, G
CHILTON, NB
BOREHAM, PFL
GRIMMOND, TR
机构
[1] SOUTH AUSTRALIAN MUSEUM,EVOLUTIONARY BIOL UNIT,ADELAIDE,SA 5001,AUSTRALIA
[2] FLINDERS UNIV,MED CTR,DEPT CLIN MICROBIOL,BEDFORD PK,SA 5042,AUSTRALIA
[3] QUEENSLAND INST MED RES,HERSTON,QLD 4006,AUSTRALIA
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
GIARDIA-INTESTINALIS; ALLOZYME ELECTROPHORESIS; CULTURE METHODS; ALLELIC CHANGES; GENE SWITCHING; SELECTION OF GENOTYPES;
D O I
10.1016/S0020-7519(05)80022-0
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The present study compares the allelic profiles of Giardia intestinalis grown in vivo and in vitro. Three clinical isolates of G. intestinalis were established in suckling mice and subsequently adapted to in vitro culture to test the null hypothesis that samples of the same clinical isolate grown in different culture conditions have identical allelic profiles. For each isolate, a mouse-derived and an axenically cultured sample were analysed electrophoretically at 11 enzyme loci. In each case, the axenically cultured sample of each isolate showed marked allelic differences from its corresponding in vivo sample. These data suggest that there may be either regulated expression of alternative genes encoding distinct isozymes (i.e. gene switching) or selection by different growth conditions of specific genotypes from a mixture present within the original clinical isolate. Although these hypotheses are not tested in this study, the data highlight the importance of confirming that allozymes (or isozymes) are stable genetic characters for the identification and characterization of protozoan taxa.
引用
收藏
页码:403 / 406
页数:4
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