ANTIGENIC SWITCHING OF TSA 417, A TROPHOZOITE VARIABLE SURFACE PROTEIN, FOLLOWING COMPLETION OF THE LIFE-CYCLE OF GIARDIA-LAMBLIA

被引：25

作者：

MENG, TC

HETSKO, ML

GILLIN, FD

机构：

[1] UNIV CALIF SAN DIEGO,MED CTR,DEPT PATHOL,SAN DIEGO,CA 92103

[2] UNIV CALIF SAN DIEGO,MED CTR,CTR MOLEC GENET,SAN DIEGO,CA 92103

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 12期

关键词：

D O I：

10.1128/IAI.61.12.5394-5397.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Expression of TSA 417, the predominant cysteine-rich variable surface protein of Giardia lamblia WB clone C6 trophozoites, did not change during encystation in vitro. However, in vitro excystation of cysts derived in vitro or in vivo consistently produced TSA 417 nonexpressing trophozoite populations, suggesting that completion of the life cycle leads to antigenic switching.

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页码：5394 / 5397

页数：4

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