CLONING OF THE MAJOR 3-MC INDUCIBLE PHASE-I AND PHASE-II DETOXIFICATION ENZYMES OF PLAICE LIVER

被引:8
作者
PIRRIT, L
HEALEY, R
ASSHETON, H
LEAVER, MJ
GEORGE, SG
机构
[1] NERC Unit of Aquatic Biochemistry, University of Stirling, Stirling
关键词
D O I
10.1016/0141-1136(94)00065-W
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
cDNA's coding for cytochrome P4501A1 (CYP1A1), phenol UDP-glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST-A) were cloned and sequenced from an expression library prepared from the liver of a 3-methylcholanthrene (3-MC) induced plaice. Plaice CYP1A1 and Phenol UDPGT display a high degree of structural conservation with homologous mammalian isoforms and their mRNAs were shown to be highly induced in liver after 3-MC treatment of fish. Expression of plaice GST-A, which displays closer homology to GSTs from plants and invertebrates than those of mammals, is repressed after 3-MC treatment.
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页码:15 / 19
页数:5
相关论文
共 11 条
[1]   FUNCTIONAL AND IMMUNOCHEMICAL COMPARISON OF HEPATIC UDP-GLUCURONOSYLTRANSFERASES IN A PISCINE AND A MAMMALIAN-SPECIES [J].
CLARKE, DJ ;
BURCHELL, B ;
GEORGE, SG .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1992, 102 (02) :425-432
[2]   MULTIPLICITY OF UDP-GLUCURONOSYLTRANSFERASES IN FISH - PURIFICATION AND CHARACTERIZATION OF A PHENOL UDP-GLUCURONOSYLTRANSFERASE FROM THE LIVER OF A MARINE TELEOST, PLEURONECTES-PLATESSA [J].
CLARKE, DJ ;
GEORGE, SG ;
BURCHELL, B .
BIOCHEMICAL JOURNAL, 1992, 284 :417-423
[3]   ACTIVITIES OF POLLUTANT METABOLIZING AND DETOXICATION SYSTEMS IN THE LIVER OF THE PLAICE, PLEURONECTES-PLATESSA - SEX AND SEASONAL-VARIATIONS IN NONINDUCED FISH [J].
GEORGE, S ;
YOUNG, P ;
LEAVER, M ;
CLARKE, D .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1990, 96 (01) :185-192
[4]  
George S.G., 1994, MOL BIOL APPROACHES, P37
[5]   ISOLATION, PROPERTIES AND INDUCTION OF PLAICE LIVER CYTOSOLIC GLUTATIONE-S-TRANSFERASES [J].
GEORGE, SG ;
BUCHANAN, G .
FISH PHYSIOLOGY AND BIOCHEMISTRY, 1990, 8 (06) :437-449
[6]   THE AH RECEPTOR IN MARINE ANIMALS - PHYLOGENETIC DISTRIBUTION AND RELATIONSHIP TO CYTOCHROME-P4501A INDUCIBILITY [J].
HAHN, ME ;
POLAND, A ;
GLOVER, E ;
STEGEMAN, JJ .
MARINE ENVIRONMENTAL RESEARCH, 1992, 34 (1-4) :87-92
[7]  
KLENOW K, 1987, ENV HLTH PERSPECT, V71, P105
[8]   CLONING AND CHARACTERIZATION OF THE MAJOR HEPATIC GLUTATHIONE-S-TRANSFERASE FROM A MARINE TELEOST FLATFISH, THE PLAICE (PLEURONECTES-PLATESSA), WITH STRUCTURAL SIMILARITIES TO PLANT, INSECT AND MAMMALIAN THETA-CLASS ISOENZYMES [J].
LEAVER, MJ ;
SCOTT, K ;
GEORGE, SG .
BIOCHEMICAL JOURNAL, 1993, 292 :189-195
[9]   CELLULAR-RESPONSES TO OXIDATIVE STRESS - THE [AH] GENE BATTERY AS A PARADIGM [J].
NEBERT, DW ;
PETERSEN, DD ;
FORNACE, AJ .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1990, 88 :13-25
[10]  
RITTER JK, 1992, J BIOL CHEM, V267, P3257