CHOLINE-ACETYLTRANSFERASE ACTIVITY OF SPINAL-CORD CELL-CULTURES IS INCREASED BY DIISOPROPYLPHOSPHOROFLUORIDATE

被引：7

作者：

BROOKES, N ^{[1
]}

GOLDBERG, AM ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG,DEPT ENVIRONM HLTH SCI,BALTIMORE,MD 21205

来源：

LIFE SCIENCES | 1979年 / 24卷 / 10期

关键词：

D O I：

10.1016/0024-3205(79)90338-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Diisopropylphosphorofluoridate (DFP) increased the specific activity of choline acetyltransferase (ChAT) in mouse spinal cord cell cultures but paraoxon did not, though both toxicants inhibited cholinesterase activity to a comparable extent. This effect of DFP was observed after prolonged exposure but not after short-term application to the cultures. It is postulated that this delayed effect of DFP in vitro may possibly be related tothe delayed neuropathy caused by DFP in certain species in vivo. © 1979.

引用

页码：889 / 894

页数：6

共 13 条

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