CONFORMATIONS OF POLY(ETHYLENE GLYCOL) BOUND HOMO-OLIGO-L-ALANINES AND HOMO-OLIGO-L-VALINES IN AQUEOUS-SOLUTION

被引：61

作者：

TONIOLO, C ^{[1
]}

BONORA, GM ^{[1
]}

MUTTER, M ^{[1
]}

机构：

[1] UNIV TUBINGEN, INST ORGAN CHEM, D-7400 TUBINGEN 1, FED REP GER

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 02期

关键词：

D O I：

10.1021/ja00496a030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A conformational analysis of poly(ethylene glycol) bound N-tert;-butyloxycarbonylhomooligo-L-alanines and L-valines to the octapeptides was performed in aqueous solution using circular dichroism. It was shown that the alanine and valine peptides may adopt β or statistical coil conformations depending upon chain length, concentration, temperature, ionic strength, presence of the N-blocking group, and pH. In addition, the β structures formed by the valine peptides are more stable than those formed by the corresponding alanine peptides. The origin of the positive dichroism near 215 nm in the homooligo-L-alanines and the effect of mono-and bifunctional poly(ethylene glycol) upon oligopeptide conformation are also discussed. © 1979, American Chemical Society. All rights reserved.

引用

页码：450 / 454

页数：5

共 36 条

[1]

ABUCHOWSKI A, 1977, J BIOL CHEM, V252, P3582

[2] VACUUM ULTRAVIOLET CIRCULAR-DICHROISM OF BETA-FORMING ALKYL OLIGOPEPTIDES [J].

BALCERSKI, JS ;

PYSH, ES ;

BONORA, GM ;

TONIOLO, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (12) :3470-3473

[3]

BONORA GM, POLYMER

[4]

BONORA GM, MAKROMOL CHEM

[5] CONFORMATIONAL TRANSITIONS OF UNCHARGED POLY-L-LYSINE . ALPHA HELIX-RANDOM COIL-BETA STRUCTURE [J].

DAVIDSON, B ;

FASMAN, GD .

BIOCHEMISTRY, 1967, 6 (06) :1616-&

[6] SOLID-STATE CONFORMATION OF MONODISPERSE HOMO-L-OLIGOPEPTIDES - X-RAY-DIFFRACTION STUDY .50. [J].

DELPRA, A ;

TONIOLO, C .

MACROMOLECULES, 1978, 11 (04) :793-797

[7] CONFORMATIONS OF POLY-L-VALINE IN SOLUTION [J].

EPAND, RF ;

SCHERAGA, HA .

BIOPOLYMERS, 1968, 6 (11) :1551-&

[8]

FUJIE A, 1973, MAKROMOL CHEM, V169, P301

[9]

GOODMAN M, 1971, Bioorganic Chemistry, V1, P310, DOI 10.1016/0045-2068(71)90024-1

[10]

GOODMAN M, 1974, PEPTIDES POLYPEPTIDE, P308

← 1 2 3 4 →