DIVERSE ACTIONS OF CADMIUM ON THE SMOOTH-MUSCLE MYOSIN PHOSPHORYLATION SYSTEM

被引：20

作者：

KOSTRZEWSKA, A

SOBIESZEK, A

机构：

[1] AUSTRIAN ACAD SCI,INST MOLEC BIOL,BILLROTHSTR 11,A-5020 SALZBURG,AUSTRIA

[2] MED ACAD BIALYSTOK,INST OBSTET & GYNECOL,PL-15062 BIALYSTOK,POLAND

来源：

FEBS LETTERS | 1990年 / 263卷 / 02期

关键词：

Cadmium; Calmodulin-Ca[!sup]2+[!/sup] complex; Myosin light chain phosphorylation; Smooth muscle;

D O I：

10.1016/0014-5793(90)81419-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of cadmium (Cd) on smooth muscle myosin phosphorylation have been investigated using an in vitro system comprising myosin filaments containing endogenous calmodulin (CM) and myosin light chain kinase (MLCKase). In the absence of calcium (Ca), Cd as well as some other divalent cations caused no activation of phosphorylation. However, when at least one (or possibly two) Ca2+ were bound per CM, the addition of 10 μM to 40 μM Cd2+ resulted in a 2 to 3 fold acceleration of the phosphorylation rate. Higher Cd concentrations caused inhibition of the system independent of Ca2+ concentration through the formation of Cd-ATP complexes. These results explain some previously controversial data on the complex effects of Cd in intact smooth muscles. © 1990.

引用

页码：381 / 384

页数：4

共 20 条

[1]

CHAO SH, 1984, MOL PHARMACOL, V26, P75

[2]

CHEUNG WY, 1985, HARVEY LECT, V79, P173

[3] CALCIUM ANTAGONISM IN HEART AND VASCULAR SMOOTH-MUSCLE [J].