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4-FOLD STRUCTURAL REPEAT IN THE ACID PROTEASES

被引：47
作者：
BLUNDELL, TL
SEWELL, BT
MCLACHLAN, AD
机构：
[1] MRC,MOLEC BIOL LAB,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND
[2] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,MOLEC BIOL LAB,LONDON WC1E 7HX,ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 580卷 / 01期
关键词：
Acid proteases; Domain structure; Gene duplication; Pepsin structure;
D O I：
10.1016/0005-2795(79)90194-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The observation that the acid proteases contain two structurally equivalent lobes related by a dyad through the active centre has been extended to show that in endothiapepsin each lobe contains two similar halves related by a further local dyad. In lobe 1 22 pairs of α-carbons are equivalent with a root mean square deviation of 1.92. Å. In lobe 2 17 pairs match within 2.31 Å. Convergent evolution or gene quadruplication may have occurred. © 1979.
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页码：24 / 31
页数：8
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