FLOW-CYTOMETRIC ANALYSIS OF LYMPHOCYTE SUBSETS IN PATIENTS WITH ADVANCED PERIODONTITIS

被引:14
作者
ZAFIROPOULOS, GGK
FLORESDEJACOBY, L
SCHOOP, B
HAVEMANN, K
HEYMANNS, J
机构
[1] UNIV MARBURG,SCH MED,DEPT PERIODONTOL,W-3550 MARBURG,GERMANY
[2] UNIV MARBURG,SCH MED,DEPT HEMATOL ONCOL IMMUNOL,W-3550 MARBURG,GERMANY
关键词
chronic inflammatory periodontal disease; lymphocytes;
D O I
10.1111/j.1600-051X.1990.tb01685.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Abstract Peripheral blood lymphocytes from 36 patients with advanced periodontitis and from 34 healthy subjects were examined using a panel of monoclonal antibodies and fluorescence flow cytometry. The absolute and relative counts of B‐cells, T‐cells, T‐helper (TH), T‐suppressor/cytotoxic (TS) cells, activated T‐cells and natural killer cells were assessed and the TH/S ratio was calculated. In the periodontitis patients, the TH/s ratio was 1.56 ± 0.62 and in the controls 1.35 ± 0.55. This was not statistically significant. A classification on the basis of sex also did not show significant differences in the TH/S ratio. B‐cells and activated T‐cells were slightly increased in the periodontitis group. However, all determined lymphocyte subpopulations revealed no significant differences between the groups. These results indicate that local inflammatory reactions and immunoregulatory dysfunction are limited to the periodontium in the patients with advanced periodontitis, with no significant quantitative effects on the peripheral lymphocyte subpopulations. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:636 / 641
页数:6
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