FUMARATE PERMEATION IN RAT-HEART MITOCHONDRIA

被引：8

作者：

PASSARELLA, S ^{[1
]}

FASANO, E ^{[1
]}

CARRIERI, S ^{[1
]}

QUAGLIARIELLO, E ^{[1
]}

机构：

[1] UNIV BARI,DEPT BIOCHEM,I-70126 BARI,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91263-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible fumarate translocation in rat heart mitochondria is examined. This substrate, which is claimed to be a non permeant ion in rat liver mitochondria appears to cross the mitochondrial membrane in cardiac mitochondria. This conclusion was proposed on the basis of experimental results which show swelling by rat heart mitochondria in ammonium fumarate, uptake by mitochondria of fumarate, Pi efflux from the matrix induced by fumarate and appearance of malate in the reaction mixture which follows the addition of fumarate to the mitochondria and depends on the fumarase activity. The existence of a carrier unknown so far as well as a possible physiological role of this transport is proposed. © 1979.

引用

页码：498 / 505

页数：8

共 23 条

[1]

BARMAN TE, 1969, ENZYMES HDB, V2, P764

[2] SWELLING AND CONTRACTION OF HEART MITOCHONDRIA SUSPENDED IN AMMONIUM CHLORIDE [J].