THE INDUCTION OF NITRIC-OXIDE SYNTHASE ACTIVITY IS INHIBITED BY TGF-BETA-1, PDGFAB AND PDGFBB IN VASCULAR SMOOTH-MUSCLE CELLS

被引：109

作者：

SCHINI, VB ^{[1
]}

DURANTE, W ^{[1
]}

ELIZONDO, E ^{[1
]}

SCOTTBURDEN, T ^{[1
]}

JUNQUERO, DC ^{[1
]}

SCHAFER, AI ^{[1
]}

VANHOUTTE, PM ^{[1
]}

机构：

[1] VET ADM MED CTR,HOUSTON,TX 77030

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期

关键词：

NITRIC OXIDE (NO); PDGF (PLATELET-DERIVED GROWTH FACTOR); TGF-BETA (TRANSFORMING GROWTH FACTOR-BETA); INTERLEUKIN-1-BETA; PLATELETS; AORTA (RAT);

D O I：

10.1016/0014-2999(92)90434-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of transforming growth factor-beta-1, (TGF-beta-1) and platelet-derived growth factor (PDGF) was investigated on the induction of nitric oxide synthase activity caused by interleukin-1-beta in cultured smooth muscle cells from rat aorta. TGF-beta-1, PDGF(AB) and PDGF(BB) but not PDGF(AA) inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1-beta. The growth factors alone did not stimulate the release of nitrite. The addition of interleukin-1-beta-treated smooth muscle cells to suspensions of indomethacin-treated human washed platelets inhibited the aggregation evoked by thrombin whereas no effect was observed with untreated cells. Platelet aggregation was not inhibited by smooth muscle cells that had been pretreated with interleukin-1-beta in combination with either TGF-beta-1, PDGF(AB) or PDGF(BB) but not with PDGF(AA). These observations demonstrate that platelet-derived products such as TGF-beta and PDGFs inhibit the induction of nitric oxide synthase activity in vascular smooth muscle cells.

引用

页码：379 / 383

页数：5

共 32 条

[1] ENDOTHELIUM-DEPENDENT INHIBITION OF PLATELET-AGGREGATION [J].