HYPOTHESIS - A DAMAGING ROLE IN AGING FOR REACTIVE PROTEIN OXIDATION-PRODUCTS

被引：37

作者：

DEAN, RT ^{[1
]}

GEBICKI, J ^{[1
]}

GIESEG, S ^{[1
]}

GRANT, AJ ^{[1
]}

SIMPSON, JA ^{[1
]}

机构：

[1] MACQUARIE UNIV,SCH BIOL SCI,SYDNEY,AUSTRALIA

来源：

MUTATION RESEARCH | 1992年 / 275卷 / 3-6期

关键词：

PROTEINS; RADICAL DAMAGE; PROTEIN-BOUND REACTIVE SPECIES;

D O I：

10.1016/0921-8734(92)90041-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper discusses our knowledge of protein oxidation and its relationship to aging. It also outlines new observations from our laboratories concerning reactive species produced during protein oxidation, and proposes that these may inflict damage on other molecules, and hence contribute to the progression of aging. Whereas it has previously been difficult to see how relatively inert protein oxidation products could possibly have any causal role in aging, the detection of these novel reactive species implies a potentially significant role.

引用

页码：387 / 393

页数：7

共 22 条

[1]

Allen R G, 1990, Annu Rev Gerontol Geriatr, V10, P198

[2] REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE [J].